SuicidDentistV1, Main, Exploration, bibRecord, 000188

Biomimetic remineralization of demineralized dentine using scaffold of CMC/ACP nanocomplexes in an in vitro tooth model of deep caries.

Identifieur interne : 000188 ( Main/Exploration ); précédent : 000187; suivant : 000189

Biomimetic remineralization of demineralized dentine using scaffold of CMC/ACP nanocomplexes in an in vitro tooth model of deep caries.

Source :

PloS one [ 1932-6203 ] ; 2015.

RBID : pubmed:25587986

Descripteurs français

KwdFr :
- Adulte (MeSH), Biomimétique (méthodes), Calcification physiologique (physiologie), Chitosane (analogues et dérivés), Chitosane (composition chimique), Collagène (composition chimique), Dent (métabolisme), Dentine (composition chimique), Humains (MeSH), Jeune adulte (MeSH), Matériaux biomimétiques (composition chimique), Nanoparticules (composition chimique), Phosphates de calcium (composition chimique), Phosphoprotéines (métabolisme), Protéines de la matrice extracellulaire (métabolisme).
MESH :
- analogues et dérivés : Chitosane.
- composition chimique : Chitosane, Collagène, Dentine, Matériaux biomimétiques, Nanoparticules, Phosphates de calcium.
- métabolisme : Dent, Phosphoprotéines, Protéines de la matrice extracellulaire.
- méthodes : Biomimétique.
- physiologie : Calcification physiologique.
- Adulte, Humains, Jeune adulte.

English descriptors

KwdEn :
- Adult (MeSH), Biomimetic Materials (chemistry), Biomimetics (methods), Calcification, Physiologic (physiology), Calcium Phosphates (chemistry), Chitosan (analogs & derivatives), Chitosan (chemistry), Collagen (chemistry), Dentin (chemistry), Extracellular Matrix Proteins (metabolism), Humans (MeSH), Nanoparticles (chemistry), Phosphoproteins (metabolism), Tooth (metabolism), Young Adult (MeSH).
MESH :
- chemical , analogs & derivatives : Chitosan.
- chemical , chemistry : Calcium Phosphates, Chitosan, Collagen.
- chemistry : Biomimetic Materials, Dentin, Nanoparticles.
- chemical , metabolism : Extracellular Matrix Proteins, Phosphoproteins, Tooth.
- methods : Biomimetics.
- physiology : Calcification, Physiologic.
- Adult, Humans, Young Adult.

Abstract

Currently, it is still a tough task for dentists to remineralize dentine in deep caries. The aim of this study was to remineralize demineralized dentine in a tooth model of deep caries using nanocomplexes of carboxymethyl chitosan/amorphous calcium phosphate (CMC/ACP) based on mimicking the stabilizing effect of dentine matrix protein 1 (DMP1) on ACP in the biomineralization of dentine. The experimental results indicate that CMC can stabilize ACP to form nanocomplexes of CMC/ACP, which is able to be processed into scaffolds by lyophilization. In the single-layer collagen model, ACP nanoparticles are released from scaffolds of CMC/ACP nanocomplexes dissolved and then infiltrate into collagen fibrils via the gap zones (40 nm) to accomplish intrafibrillar mineralization of collagen. With this method, the completely demineralized dentine was partially remineralized in the tooth mode. This is a bottom-up remineralizing strategy based on non-classical crystallization theory. Since nanocomplexes of CMC/ACP show a promising effect of remineralization on demineralized dentine via biomimetic strategy, thereby preserving dentinal tissue to the maximum extent possible, it would be a potential indirect pulp capping (IPC) material for the management of deep caries during vital pulp therapy based on the concept of minimally invasive dentistry (MID).

DOI: 10.1371/journal.pone.0116553
PubMed: 25587986
PubMed Central: PMC4294661

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000184
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Le document en format XML

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<author><name sortKey="Cong, Changhong" sort="Cong, Changhong" uniqKey="Cong C" first="Changhong" last="Cong">Changhong Cong</name>
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<author><name sortKey="Li, Yanqiu" sort="Li, Yanqiu" uniqKey="Li Y" first="Yanqiu" last="Li">Yanqiu Li</name>
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<author><name sortKey="Wang, Huajun" sort="Wang, Huajun" uniqKey="Wang H" first="Huajun" last="Wang">Huajun Wang</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Biomimetic Materials (chemistry)</term>
<term>Biomimetics (methods)</term>
<term>Calcification, Physiologic (physiology)</term>
<term>Calcium Phosphates (chemistry)</term>
<term>Chitosan (analogs & derivatives)</term>
<term>Chitosan (chemistry)</term>
<term>Collagen (chemistry)</term>
<term>Dentin (chemistry)</term>
<term>Extracellular Matrix Proteins (metabolism)</term>
<term>Humans (MeSH)</term>
<term>Nanoparticles (chemistry)</term>
<term>Phosphoproteins (metabolism)</term>
<term>Tooth (metabolism)</term>
<term>Young Adult (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term>
<term>Biomimétique (méthodes)</term>
<term>Calcification physiologique (physiologie)</term>
<term>Chitosane (analogues et dérivés)</term>
<term>Chitosane (composition chimique)</term>
<term>Collagène (composition chimique)</term>
<term>Dent (métabolisme)</term>
<term>Dentine (composition chimique)</term>
<term>Humains (MeSH)</term>
<term>Jeune adulte (MeSH)</term>
<term>Matériaux biomimétiques (composition chimique)</term>
<term>Nanoparticules (composition chimique)</term>
<term>Phosphates de calcium (composition chimique)</term>
<term>Phosphoprotéines (métabolisme)</term>
<term>Protéines de la matrice extracellulaire (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Chitosan</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Calcium Phosphates</term>
<term>Chitosan</term>
<term>Collagen</term>
</keywords>
<keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Chitosane</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Biomimetic Materials</term>
<term>Dentin</term>
<term>Nanoparticles</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Chitosane</term>
<term>Collagène</term>
<term>Dentine</term>
<term>Matériaux biomimétiques</term>
<term>Nanoparticules</term>
<term>Phosphates de calcium</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Extracellular Matrix Proteins</term>
<term>Phosphoproteins</term>
<term>Tooth</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Biomimetics</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Dent</term>
<term>Phosphoprotéines</term>
<term>Protéines de la matrice extracellulaire</term>
</keywords>
<keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Biomimétique</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Calcification physiologique</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Calcification, Physiologic</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Humans</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Humains</term>
<term>Jeune adulte</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Currently, it is still a tough task for dentists to remineralize dentine in deep caries. The aim of this study was to remineralize demineralized dentine in a tooth model of deep caries using nanocomplexes of carboxymethyl chitosan/amorphous calcium phosphate (CMC/ACP) based on mimicking the stabilizing effect of dentine matrix protein 1 (DMP1) on ACP in the biomineralization of dentine. The experimental results indicate that CMC can stabilize ACP to form nanocomplexes of CMC/ACP, which is able to be processed into scaffolds by lyophilization. In the single-layer collagen model, ACP nanoparticles are released from scaffolds of CMC/ACP nanocomplexes dissolved and then infiltrate into collagen fibrils via the gap zones (40 nm) to accomplish intrafibrillar mineralization of collagen. With this method, the completely demineralized dentine was partially remineralized in the tooth mode. This is a bottom-up remineralizing strategy based on non-classical crystallization theory. Since nanocomplexes of CMC/ACP show a promising effect of remineralization on demineralized dentine via biomimetic strategy, thereby preserving dentinal tissue to the maximum extent possible, it would be a potential indirect pulp capping (IPC) material for the management of deep caries during vital pulp therapy based on the concept of minimally invasive dentistry (MID). </div>
</front>
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<Month>11</Month>
<Day>13</Day>
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<ArticleTitle>Biomimetic remineralization of demineralized dentine using scaffold of CMC/ACP nanocomplexes in an in vitro tooth model of deep caries.</ArticleTitle>
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<Abstract><AbstractText>Currently, it is still a tough task for dentists to remineralize dentine in deep caries. The aim of this study was to remineralize demineralized dentine in a tooth model of deep caries using nanocomplexes of carboxymethyl chitosan/amorphous calcium phosphate (CMC/ACP) based on mimicking the stabilizing effect of dentine matrix protein 1 (DMP1) on ACP in the biomineralization of dentine. The experimental results indicate that CMC can stabilize ACP to form nanocomplexes of CMC/ACP, which is able to be processed into scaffolds by lyophilization. In the single-layer collagen model, ACP nanoparticles are released from scaffolds of CMC/ACP nanocomplexes dissolved and then infiltrate into collagen fibrils via the gap zones (40 nm) to accomplish intrafibrillar mineralization of collagen. With this method, the completely demineralized dentine was partially remineralized in the tooth mode. This is a bottom-up remineralizing strategy based on non-classical crystallization theory. Since nanocomplexes of CMC/ACP show a promising effect of remineralization on demineralized dentine via biomimetic strategy, thereby preserving dentinal tissue to the maximum extent possible, it would be a potential indirect pulp capping (IPC) material for the management of deep caries during vital pulp therapy based on the concept of minimally invasive dentistry (MID). </AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Zhen</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>School of Stomatology, Hospital of Stomatology, Tianjin Medical University, Tianjin, PR China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cao</LastName>
<ForeName>Shansong</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>School of Stomatology, Hospital of Stomatology, Tianjin Medical University, Tianjin, PR China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Haorong</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>School of Stomatology, Hospital of Stomatology, Tianjin Medical University, Tianjin, PR China.</Affiliation>
</AffiliationInfo>
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	Serveur d'exploration sur le suicide chez les dentistes
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Serveur d'exploration sur le suicide chez les dentistes

Biomimetic remineralization of demineralized dentine using scaffold of CMC/ACP nanocomplexes in an in vitro tooth model of deep caries.

Biomimetic remineralization of demineralized dentine using scaffold of CMC/ACP nanocomplexes in an in vitro tooth model of deep caries.

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